TextBlob is a Python (2 and 3) library for processing textual data. It provides a simple API for diving into common natural language processing (NLP) tasks such as part-of-speech tagging, noun phrase extraction, sentiment analysis, classification, translation, and more.
Scrapy is a fast high-level screen scraping and web crawling framework, used to crawl websites and extract structured data from their pages. It can be used for a wide range of purposes, from data mining to monitoring and automated testing.
pyo is a Python module written in C to help digital signal processing script creation.
MediaGoblin is a free software media publishing platform that anyone can run. You can think of it as a decentralized alternative to Flickr, YouTube, SoundCloud, etc.
Flask is a microframework for Python based on Werkzeug, Jinja 2 and good intentions. And before you ask: It's BSD licensed!
ghost.py is a webkit web client written in python.
A system for coordinating the activities of users via their mobile phones.
Command-line interface description language. docopt helps you define interface for your command-line app, and automatically generate parser for it.
Command Line Interface Formulation Framework. cliff is a framework for building command line programs. It uses plugins to define sub-commands, output formatters, and other extensions.
Alembic is a new database migrations tool, written by the author of SQLAlchemy.
Pyramid is a very general open source Python web framework.
sh (previously pbs) is a full-fledged subprocess interface for Python that allows you to call any program as if it were a function